Effects of the Peroxisome proliferator-activated receptor γ (PPARγ) ligands on cancer cells
نویسندگان
چکیده
منابع مشابه
Relaxin activates peroxisome proliferator-activated receptor γ (PPARγ) through a pathway involving PPARγ coactivator 1α (PGC1α).
Relaxin activation of its receptor RXFP1 triggers multiple signaling pathways. Previously, we have shown that relaxin activates PPARγ transcriptional activity in a ligand-independent manner, but the mechanism for this effect was unknown. In this study, we examined the signaling pathways of downstream of RXFP1 leading to PPARγ activation. Using cells stably expressing RXFP1, we found that relaxi...
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PPARγ is a nuclear transcription factor and the pharmacologic target for antidiabetic thiazolidinediones (TZDs). TZDs ameliorate diabetic nephropathy and have direct effects on cultured mesangial cells (MCs), however in situ hybridization failed to detect expression of PPARγ in glomeruli in vivo. The purpose of this study was to determine whether PPARγ is expressed in renal glomeruli. Two rabbi...
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ژورنال
عنوان ژورنال: Journal of Cellular Immunotherapy
سال: 2017
ISSN: 2352-1775
DOI: 10.1016/j.jocit.2017.04.039